You can never be slim or rich enough, said the late duchess of Windsor; but can you ever be too worried about your health? Epidemiologists are always finding new things for us to fret about, new threats in the environment for us to avoid if we can or bite our nails over if we can’t. It is, as the French say, their métier.
One of the latest scares is over a parasite called Toxoplasma gondii, a protozoon parasite that until recently was thought to be harmless for everyone except for the fetuses of pregnant women and people with much reduced immunity, for example patients with AIDS or Hodgkin’s lymphoma. This parasite is, if not quite ubiquitous, very common, so if it really is harmful there might be a lot to worry about. This is no time for complacency: where health scares are concerned, it never is.
The definitive host of the Toxoplasma parasite is the domestic cat, but it can be passed on to other animals, especially those that provide us with our animal protein (although cattle are relatively resistant to infection), and it thus enters the human food chain.
A recent editorial in The Lancet contains a sentence that could become a locus classicus of epidemiological neurosis. Having pointed out “the widely held view that Toxoplasma gondii contamination in food and human infection in general should not cause public concern,” it goes on to say, “However, infections could have as yet poorly understood adverse consequences.” That no definite adverse consequences have not yet been discovered does not necessarily mean that they are not there; there is an old medical dictum that says that absence of evidence is not evidence of absence. Relaxation, about anything then, can never be justified.
But is there any evidence that infection with Toxoplasma gondii is actually harmful except to restricted groups (in whom, indeed, it can be very serious indeed)? The Lancet editorial refers to two pieces of research, one from Denmark and the other from the United States, that suggest that infection might do neuropsychiatric harm.
Danish researchers found that women who had antibodies against the parasite were more likely than those who did not to make suicide attempts, particularly by violent methods. (Although Denmark is a small country with a small population, it has a remarkable record of medical research on large numbers of people.) Altogether 45,788 women had their blood checked for antibodies against Toxoplasma while they were pregnant, and it was found that those who tested positive were 1.53 times as likely to attempt suicide as those who did not; moreover, the risk increased with higher levels of antibody.
In the United States, researchers found that people who suffered from bipolar affective disorder (both mania and depression) had an increased prevalence of seropositivity for Toxoplasma.
As the editorial points out, correlation is not causation; it could be, for example, that people with certain behavioral propensities are more likely to become infected with Toxoplasma. But it also points out that the parasite, which enters the human brain, has genes that can modify the production of the neurotransmitters that according to modern neuro-scientific doctrine play a determining role in our mood and conduct.
Dogs can be infected by Toxoplasma as well as humans, and the infection sometimes causes them serious symptoms. They are infected by cat feces, and indeed without cats there would be no toxoplasmosis. No wonder that dogs act on a variant of Dick’s famous advice in Henry VI Part 2: The first thing we do, let’s kill all the cats.
First published in PJ Media.